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Naturally-occurring serotype 3 Streptococcus pneumoniae strains that lack functional pneumolysin and autolysin have attenuated virulence but induce localized protective immune responses.
Ηαnnah E Wong, Panagiotis Tourlomousis, Gavin K Paterson, Steve Webster, Clare E Bryant
Apr 09, 2023
Streptococcus pneumoniae is an important cause of fatal pneumonia in humans. These bacteria express virulence factors, such as the toxins pneumolysin and autolysin, that drive host inflammatory responses. In this study we...
Animals Horses Mice Streptococcus pneumoniae N-Acetylmuramoyl-L-alanine Amidase Tumor Necrosis Factor-alpha Bacterial Proteins Streptolysins Virulence Immunity Serogroup
Published by: PLOS ONE
Impact of Leadership on the Relationship Between Innovation and Performance
Leadership, innovation, and performance are essential factors to achieve the desired sustainable profitability of companies. The relationship between these variables is one of the keys to the organizational success, although...
Business and Management Hospitality, Travel, and Tourism Management Hospitality, Travel, & Tourism Management
Published by: IGI Global
Label-free cell segmentation of diverse lymphoid tissues in 2D and 3D.
John W Wills, Jack Robertson, Pani Tourlomousis, Clare M C Gillis, Claire M Barnes, Michelle Miniter, Rachel E Hewitt, Clare E Bryant, Huw D Summers, Jonathan J Powell, Paul Rees
Apr 17, 2023
Unlocking and quantifying fundamental biological processes through tissue microscopy requires accurate, in situ segmentation of all cells imaged. Currently, achieving this is complex and requires exogenous fluorescent...
confocal microscopy immunofluorescence Tissue Quantitative Cell segmentation 3D digital pathology Label Free 2D single-cell
Published by: Cell reports methods
Structural brain alterations associated with suicidal thoughts and behaviors in young people
Laura S. van Velzen, Maria R. Dauvermann, Lejla Colic, Luca M. Villa, Hannah S. Savage, Yara J. Toenders, Alyssa H. Zhu, Joanna K. Bright, Adrián I. Campos, Lauren E. Salminen, Sonia Ambrogi, Rosa Ayesa-Arriola, Nerisa Banaj, Zeynep Başgöze, Jochen Bauer, Karina Blair, Robert James Blair, Katharina Brosch, Yuqi Cheng, Romain Colle, Colm G. Connolly, Emmanuelle Corruble, Baptiste Couvy-Duchesne, Benedicto Crespo-Facorro, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Katharina Dohm, Janice M. Fullerton, Ali Saffet Gonul, Ian H. Gotlib, Dominik Grotegerd, Tim Hahn, Ben J. Harrison, Mengxin He, Ian B. Hickie, Tiffany C. Ho, Frank Iorfino, Andreas Jansen, Fabrice Jollant, Tilo Kircher, Bonnie Klimes-Dougan, Melissa Klug, Elisabeth J. Leehr, Elizabeth T. C. Lippard, Katie A. McLaughlin, Susanne Meinert, Adam Bryant Miller, Philip B. Mitchell, Benson Mwangi, Igor Nenadić, Amar Ojha, Bronwyn J. Overs, Julia-Katharina Pfarr, Fabrizio Piras, Kai G. Ringwald, Gloria Roberts, Georg Romer, Marsal Sanches, Margaret A. Sheridan, Jair C. Soares, Gianfranco Spalletta, Frederike Stein, Giana I. Teresi, Diana Tordesillas-Gutiérrez, Aslihan Uyar-Demir, Nic J. A. van der Wee, Steven J. van der Werff, Robert R. J. M. Vermeiren, Alexandra Winter, Mon-Ju Wu, Tony T. Yang, Paul M. Thompson, Miguel E. Rentería, Neda Jahanshad, Hilary P. Blumberg, Anne-Laura van Harmelen, Lianne Schmaal
Apr 07, 2023